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ELISA Kit for Thiopurine Methyltransferase TPMT

Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase) catalyzes thiopurine S-methylation, an important metabolic pathway for antineoplastic and immunosuppressive drugs. In the US, 11% of the population show intermediate TPMT activity, and approximately 1 in 300 have TPMT deficiency. Thiopurine Methyltransferase Phenotype. 6-mercaptopurine and related thiopurine compounds. TPMT genotyping is preferred to phenotyping as a first line test. Thiopurine methyltransferase (TPMT) deficiency is a condition in which patients treated with standard doses of azathioprine (AZA, Imuran), 6-mercaptopurine (6-MP, Purinethol), or 6-thioguanine (6-TG, Thioguanine Tabloid) may develop life-threatening myelosuppression or severe hematopoietic toxicity. This is a next generation sequencing (NGS) test appropriate for individuals with clinical signs and symptoms, suspicion of, or family history of Thiopurine S-Methyltransferase Deficiency.

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ON, CA. Test Version. 30-Sep-2019. Specimen.


Use: Detection of polymorphisms within the  Testing for TPMT: Until recently, TMPT testing was only available as a research test. However, there are now several laboratories conducting commercially  Abstract.

Thiopurine methyltransferase test

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Thiopurine methyltransferase test

2019-07-26 Clinical test for Thiopurine methyltransferase deficiency offered by Labor Dr. Wisplinghoff Phenotype test to assess risk for severe myelosuppression with standard dosing of thiopurine drugs. Testing should be performed prior to initiation of thiopurine therapy.

Thiopurine methyltransferase test

One or the other of these tests is used to identify individuals at risk of developing severe side effects from thiopurine therapy. Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene.
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Thiopurine methyltransferase test

Prometheus Biosciences is certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high-complexity clinical laboratory testing and is accredited by the College of American Pathologists (CAP). Specimen Required.

UGT1A1 buprenorfin indakaterol irinotekan östrogen. Ca 5-10% av  Välj begynnelsebokstav för önskad analys. Klicka på analysen för att få mer information. Samtliga analyser är beställningsbara i Cosmic.
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Xaluprine, INN-mercaptopurine -

Thiopurine methyltransferase (TPMT) deficiency is a condition in which patients treated with standard doses of the immunosuppressant azathioprine or the antineoplastic drug 6-mercaptopurine (6-MP) may develop life-threatening myelosuppression or severe hematopoietic toxicity. View protein in InterPro IPR029063, SAM-dependent_MTases IPR025835, Thiopurine_S-MeTrfase IPR008854, TPMT: Pfam i: View protein in Pfam PF05724, TPMT, 1 hit: PIRSF i: PIRSF023956, Thiopurine_S-methyltransferase, 1 2018-02-22 · Normal TPMT activity: 25-65 U/mL - Individuals are predicted to be at low risk of bone marrow toxicity as a consequence of standard thiopurine therapy; no dose adjustment is recommended.

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It is a prodrug of mercaptopurine, a substance that is subsequently metabolised by several alternative pathways, one of which involves the enzyme thiopurine methyltransferase (TPMT). Thiopurine S-methyltransferase (TPMT) is an enzyme that the body uses to break down thiopurine drugs. Thiopurine S-methyltransferase deficiency patients have a mutation in either one or both copies of the TPMT gene that causes reduced enzyme activity and difficulties breaking down thiopurine drugs. Background: Evaluation of TPMT status prior to prescribing azathioprine. Both TPMT activity and genetic analysis are performed by the referral laboratory. The TPMT gene provides instructions for making an enzyme called thiopurine S-methyltransferase (TPMT). This enzyme carries out a specific chemical reaction called S-methylation of a group of molecules known as aromatic and heterocyclic sulphydryl compounds.